Nitrofurantoin dosage form

Details Nitrofurantoin dosage form Nitrofurantoin dosage form

1986-06-16

1988-09-20

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424 80, 424 81, 424451, 424452, 424458, 424489, A61K 952, A61K 954, A61K 31345

Patent

active

047724730

ABSTRACT:
The invention involves a combination sustained release/rapid release pharmaceutical capsule for oral administration of nitrofurantoin comprising, in a capsule shell, a first layer of a first particulate mixture comprising nitrofurantoin, polyvinylpyrrolidone and carboxyvinylpolymer; and a second layer of a second particulate mixture comprising macrocrystalline nitrofurantoin.

REFERENCES:
patent: 2610181 (1952-09-01), Hayes
patent: 3401221 (1968-09-01), Borgmann et al.
patent: 3427378 (1969-02-01), Henderson et al.
patent: 3444290 (1969-05-01), Wai
patent: 3458622 (1969-07-01), Hill
patent: 3634584 (1972-01-01), Poole
patent: 4016254 (1977-04-01), Seager
patent: 4122157 (1978-10-01), Huber
patent: 4126672 (1978-11-01), Sheth et al.
patent: 4152444 (1979-05-01), Vischer et al.
patent: 4252786 (1981-02-01), Weiss et al.
patent: 4343789 (1982-08-01), Kawata et al.
patent: 4370313 (1983-01-01), Davies
patent: 4404183 (1983-09-01), Kawata et al.
patent: 4610875 (1986-09-01), Panoz et al.
El Egakey, M. A., "In Vitro and in Vivo Release Studies of Nitrofurantoin from Coated Crystals", Acta Pharmaceutica Technologica, vol. 28, No. 4 (1982).

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