Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-02-28
2006-02-28
Wilson, James O. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S021000, C536S055100, C536S055200, C536S055300, C536S124000, C514S054000, C514S056000, C514S834000
Reexamination Certificate
active
07005508
ABSTRACT:
The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic acid and/or hexosamine, containing nitro groups —ONO2covalently bonded to the saccharide structure. Preferably, the polysaccharides according to the invention are prevalently formed of disaccharide repeating units formed of uronic acid and hexosamine. These compounds, in psychological conditions, selectively release NO, allowing a reduction in the amount of NO needed to achieve a determined therapeutical effect. This result has been achieved by functionalizing polysaccharides essentially formed of units of uronic acid and/or hexosamine, with subsituents containing a ONO2 ? group.
REFERENCES:
patent: 2662078 (1953-12-01), Haddian et al.
patent: 5019649 (1991-05-01), Lormeau et al.
patent: 5763504 (1998-06-01), Matsuda et al.
patent: 417556 (1934-10-01), None
patent: 2 261 663 (1993-05-01), None
patent: WO 99/27976 (1999-06-01), None
Gresele et al.,Thromb. Haemost., 55: 12-18 (1986).
Momi et al.,Haematologica, 86: 297-302 (2001).
Nagasawa et al.,Carbohydr. Res., 158: 183-190 (1986).
Naggi et al.,Biochem. Pharmacol., 36: 1895-1900 (1987).
Ogamo et al.,Carbohydr. Res., 193: 165-172 (1989).
Rey et al.,Carbohydr. Res., 210: 299-310 (1991).
Saavedra et al.,Bioorganic&Medic. Chem. Lett., 10: 751-753 (2000).
Vezza et al.,Blood, 82: 2704-2713 (1993).
Benedini Francesca
Casu Benito
Del Soldato Piero
Gresele Paolo
Naggi Annamaria
NicOx S.A.
O'Brien David G.
White Everett
Yankwich Leon R.
Yankwich & Associates P.C.
LandOfFree
Nitroderivatives of polysaccharides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nitroderivatives of polysaccharides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitroderivatives of polysaccharides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3644995