Nitrobenzylmercaptopurineriboside (NBMPR)-insensitive, equilibra

Details Nitrobenzylmercaptopurineriboside (NBMPR)-insensitive, equilibra Nitrobenzylmercaptopurineriboside (NBMPR)-insensitive, equilibra

1998-04-09

2000-10-10

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4352523, 4352542, 435325, 435366, 435372, 436 94, 536 231, 536 2433, C12P 2106

Patent

active

061300659

ABSTRACT:
An isolated NBMPR-insensitive equilibrative nucleoside transport protein (iENTP) and the nucleic acid encoding it is disclosed. The iENTP can be used in screening assays to identify both natural nucleoside permeants and/or inhibitors and analogs thereof. In addition, transfected or transduced cell lines are disclosed which use the iENTP as the sole nucleoside transport protein. Methods of employing such cell lines for drug screening are also included. Furthermore methods of using hematopoietic stem cells transduced with an iENTP in a chemotherapy protocol is also described. In addition, methods of using these cells to selectively express a heterologous gene for gene therapy is disclosed.

REFERENCES:
New England Biolabs Catalog 1996/1997, p. 111.
Belt, Mol. Pharmacol., 24:479-484 (1983).
Belt et al. Advan. Enzyme Regul., 33:235-252 (1993).
Cass, in Drug Transport in Antimicrobial Therapy and Anticancer Therapy (N.H. Georgopapadakou, ed.(Marcel Dekker)), 403-451 (1995).
Crawford et al., 1998, J Biol Chem, 273:5288-93.
Dahlig-Harley et al., Biochem J. 200:295-305 (1981).
Fang et al., Biochem. J., 317:457-465 (1996).
Gati and Paterson, in The red cell membrane: structure, function, and clinical implications, P. Agre and J.C. Parker, eds., (New York: Marcel Decker), pp. 635-661 (1989).
Griffith et al., Biochim. Bioph. Acta 1286:153-181 (1996).
Griffiths et al., Nature Med. 3:89-93 (1997).
Hammond, J. Pharmacol. Exp. Ther., 259:799-807 (1991).
Huang et al., J. Biol. Chem., 268:20613-20620 (1993).
Huang et al., J. Biol. Chem., 269:17757-17760 (1994).
Jarvis, in Adenosine Receptors, D.M.F. Cooper and C. Londos, eds., (New York: Alan R. Liss, Inc.), pp. 113-123 (1988).
Jarvis, Mol. Pharmacol., 30:659-665 (1986).
New England Biolabs Catalog, 1993/94, pp93-94.
Paterson et al., Mol. Parmacol., 18:40-44 (1980).
Paterson and Cass, in Membrane Transport of Antineoplastic Agents, I.D. Goldman, ed., (New York: Pergamon Press), pp. 309-329 (1986).
Pajor et al., J. Biol. Chem., 267:3557-3560 (1992).
Parkinson et al., Gen. Pharmacol. 25:1053-1058 (1994).
Plagemann et al., Biochim. Biophys. Acta., 969:1-8 (1984).
Plagemann and Wohlheuter, Biochim. Biophys. Acta., 773:39-52 (1984).
Plagemann and Wohlheuter, Curr. Topics Membr. Trans., 14:225-330 (1980).
Ritzel et al. Am. J. Physiol. (1997).
Rongen et al., J. Clin. Invest. 95:658-668 (1995).
Ullman et al., J. Biol. Chem. 263:12391-12396 (1988).
Vijayalakshmi et al., J. Biol. Chem., 263:19419-19423 (1988).
Williams et al., Biochem. J.264:223-231 (1991).
Williams et al. (1995) Biochem. Biophys. Res. Comm. 213-325-33.
Wu et al., J. Biol. Chem., 267:8813-8818 (1992).
Yao et al., 1997, J Biol Chem, 272:28423-30.

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