Nitroaniline derivatives and their use as anti-tumour agents

Details Nitroaniline derivatives and their use as anti-tumour agents Nitroaniline derivatives and their use as anti-tumour agents

1996-07-23

1998-05-12

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564163, C07C23365

Patent

active

057507821

ABSTRACT:
The invention provides nitroaniline derivatives represented by general formula (1) where the nitro group is substituted at any one of the available benzene positions 2-6; where R and A separately represent the groups NO.sub.2, CN,COOR.sup.1, CONR.sup.1 R.sup.2, CSNR.sup.1 R.sup.2 or SO.sub.2 NR.sup.1 R.sup.2 and A is substituted at any one of the available benzene positions 2-6; where B represents N(CH.sub.2 CH.sub.2 halogen).sub.2 or N(CH.sub.2 CH.sub.2 OSO.sub.2 R.sup.3).sub.2 substituted at any one of the available benzene positions; and where R.sup.1, R.sup.2 and R.sup.3 separately represent H, or lower alkyl optionally substituted with hydroxyl, ether, carboxy or amino functions, including cyclic structures, or R.sup.1 and R.sup.2 together with the nitrogen form a heterocyclic structure, and pharmaceutical preparations containing them. These compounds have activity as hypoxia-selective cytotoxins, reductively-activated prodrugs for cytotoxins, hypoxic cell radiosensitisers, and anticancer agents. ##STR1##

REFERENCES:
patent: 5171889 (1992-12-01), Anderson
Palmer et al., "Hypoxia-Selective . . . Cells", J. or Medicinal Chemistry, vol. 35, No. 17, pp. 3214-3222., Aug. 1992.

Affiliated with

Also associated with

Rating

Nitroaniline derivatives and their use as anti-tumour agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitroaniline derivatives and their use as anti-tumour agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitroaniline derivatives and their use as anti-tumour agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-981147