Organic compounds -- part of the class 532-570 series – Organic compounds
Patent
1998-01-23
2000-06-27
Marschel, Ardin H.
Organic compounds -- part of the class 532-570 series
Organic compounds
435 6, 536 221, 536 253, 548120, 548146, 548148, 548181, 548215, 548217, 548223, C07D29300
Patent
active
060808683
ABSTRACT:
The invention provides an asymmetric cyanine dye compound having the structure ##STR1## including substituted forms thereof, wherein, at least one of R.sub.1 and R.sub.2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labeled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labeled polynucleotides.
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Graham Ronald J.
Haxo Francis T.
Lee Linda G.
Mullah Khairuzzaman B.
Andrus Alex
Grossman Paul
Marschel Ardin H.
The Perkin-Elmer Corporation
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