Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-12-02
1992-03-24
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514385, 5482648, 548300, A01N 4364, A61K 3141, C07D24917, C07D23300
Patent
active
050989219
ABSTRACT:
A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.
REFERENCES:
patent: 4323689 (1982-04-01), Vogel et al.
Int. J. Radiat. Biol. (1972), vol. 21, No. 5, pp. 475-482, (J. D. Chapman et al).
Biochemical Pharmacology vol. 35, No. 7, pp. 1107-1112 (1986), (A. R. Silver and P. O'Neill).
J. Chem. Soc. Faraday Trans. I, 72, 1377-1390 (1976), (P. Wardman and E. D. Clarke).
Cancer Research, 32, pp. 2616-2624, Dec. 1972, (J. D. Chapman et al).
Adams Gerald E.
Fielden Edward M.
Jenkins Terence C.
Stratford Ian J.
Covington Raymond
Ivy C. Warren
National Research Development Corporation
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