Nitro-substituted aromatic or hetero-aromatic compounds for use

Details Nitro-substituted aromatic or hetero-aromatic compounds for use Nitro-substituted aromatic or hetero-aromatic compounds for use

1994-12-09

1996-05-28

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514385, 514396, A01N 4364, A61K 3141, C07D24914, C07D23300

Patent

active

055212034

ABSTRACT:
A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.

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