Nitro-substituted 1-.beta.-D-arabinofuranosylcytosines

Details Nitro-substituted 1-.beta.-D-arabinofuranosylcytosines Nitro-substituted 1-.beta.-D-arabinofuranosylcytosines

1982-02-22

1987-03-24

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 23, C07H 1700, A61K 3170

Patent

active

046525548

ABSTRACT:
1-(2-O-Nitro-.beta.-D-arabinofuranosyl)cytosine and salts, anti-leukemics.

REFERENCES:
patent: 3595853 (1971-07-01), Kanai et al.
Goodman and Gilman, The Pharmacological Basis of Therapeutics (3rd Ed., 1966), pp. 1345-1379.
Goodman and Gilman, ibid, (6th Ed., 1980), pp. 1256-1301.
Therapaeia, May 1981, pp. 11-27.
Cancer Facts and Figures Am. Can. Soc. (1970), pp. 3-5, 16-19.
Ibid (1983), p. 3-7, 12-19.
Furth and Cohen, Can. Res., 28, 2061 (1968).
Chwang, Fridland and Avery, J. Med. Chem., 28, 280 (1983).
Ho, Cancer Research, 33, 2816 (1973).
Matsushita et al., Cancer Research, 41, 2707 (1981).
Gray et al., Biochemical Pharmacology, 21, 465 (1972).
Kataoka and Sakurai, "Research Results in Cancer Research", 70, 147-151 (Editors, Carter & Sakurai, Springer-Verlag, New York 1980).
Bobek et al., J. Med. Chem., 21, 597 (1978).
Cheng et al., Cancer Research, 41, 3144 (1981).
Kreis et al., Helv. Chim. Acta., 61, 1011 (1978).
Venditti et al., Can. Chem. Rep., 56, 483 (1972).
Burgess et al., Can. Treat. Rep., 61, 437 (1977).
Hamamura et al., J. Med. Chem., 663 (1966).
Kondo et al., J. Org. Chem., 45, 1577 (1980).
Chwang et al., AACR Abstracts, Mar. 1981, Abstract 895.

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