Nitriles

Details Nitriles Nitriles

1987-03-09

1988-07-26

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

546245, 558369, 558431, 558432, C07C12146

Patent

active

047601582

ABSTRACT:
Novel 3-halo-2,2-disubstituted propanenitriles of formula ##STR1## wherein Z represents bromo or chloro and A, together with the carbon atom to which it is attached, represents a 5,6 or 7 membered saturated carbocyclic or heterocyclic ring, are useful as intermediates for preparing substituted pyrimido[1,2-a]indoles. The intermediates can be prepared by a novel process which comprises condensing a 2,2-disubstituted ethanenitrile with a dihalomethane in the presence of a non-nucleophilic strong base.

REFERENCES:
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patent: 4442122 (1984-04-01), Engelhart et al.
C. A., 102: 95510c, Overman et al., (1985).
C. A., 83: 42876j; Larcheveque, et al., (1975).
C. A., 81: 120399f, Larcheveque, et al., (1974).
Makosza and Serafin, Chem. Abstracts, vol. 66, 94792x, (1967).
Steiner et al., Chem. Abstracts, vol. 77, 57976s, (1972).

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