Nitric oxide synthase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514565, A61K 31195

Patent

active

055854028

ABSTRACT:
The present invention discloses a method for inhibiting tissue damage in mammals caused by pathological NO production, which comprises administering an effective tissue damage inhibition amount of a NO synthase inhibitor to said mammal. Preferably the NO synthase inhibitor is L-NMMA.

REFERENCES:
patent: 4282217 (1981-08-01), Baglioni et al.
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5158883 (1992-10-01), Griffith
patent: 5356873 (1994-10-01), Mark et al.
CA 118:78331, Nava et al., 1992.
Tissue injury caused by depostion of immune complexes is L-arginine dependent; vol. 88 pp. 6338-6342, Jul. 1991; Medical Sciences; Michael S. Mulligan et al.
Beckman, J. S. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Dev. Physiol. (Eynsham). 15: 53-60, 1991.
Li, L. et al. Role of nitric oxide lysis of tumor cells by cytokine-activated endothlial cells. Cancer Res. 51: 2531-2535, 1991.
Nakaki, T. et al. Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 3: 347-353, 1990.
Boughton Smith, N. K. et al. Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat. Eur. J. Pharmacol. 191: 485-488, 1990.
Hutcheson, I. R. et al. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br. J. Pharmacol. 101: 815-820, 1990.
Kilbourn, R. G. et al. Reversal of Endotoxin-mediated shock by N.sup.G -methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem. Biophys. Res. Comm. 172(3): 1132-1138, 1990.
Marshall, J. J. et al. Endothelium-derived relaxing factors. A perspective from in vivo data. Hypertension 16: 371-386, 1990.
Rubanyi, G. M. et al. Cytoprotective function of nitric oxide inactivation of superoxide radicals produced by human leukocytes. Biochem. Biophys. Res. Commun. 181: 1392-1397, 1991.
Palmer, R. M. J. et al. The role of ntric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br. J. Pharmacol. 105: 11-12, 1992.
Wright, C. E. et al. Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc. Res. 26: 48-57, 1992.
Ialenti, A. et al. Modulation of acute inflammation by endogenous nitric oxide. Eur. J. Pharmacol. 211: 177-182, 1992.
Bergmann, L. et al. Cytotoxic action of IL-1B against pancreatic islets is mediated via nitric oxide formation and is inhibited by N.sup.G -monomethyl-L-arginine. Febs (Fed. Eur. Biochem. Soc.). Lett. 299: 103-106, 1992.
Langrehr, J. M. et al. Evidence that nitric oxide production by in-vivo allosensitized cells inhibits the development of allospecific CTL. Transplantation (Baltimore) 53:632-640, 1992.
Demerle Pallardy, C. et al. Absence of implication of L-arginine
itric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia. Biochem. Biophys. Res. Commun. 181: 456-464, 1991.
Billiar, T. R. et al. Modulation of nitrogen oxide synthesis in vivo: N.sup.G -monomethyl-L-arginine inhibits endotoxin-induced nitrite
itrate biosynthesis while promoting hepatic damage. J. Leuk. Biol. 48: 565-569, 1990.
Ochoa, J. B. et all. Nitrogen oxide levels in patients after trauma and during sepsis. Ann. Surg. 214: 621-626, 1991.
Bone, R. C. The pathogenesis of sepsis. Ann. Intern. Med. 115:457-469, 1991.
Dal Nogare, A. R. Septic shock. Am. J. Med. Sci. 302: 50-65, 1991.
Nava, E. et al. The role of nitric of nitric oxide in endotoxic shock. (Corresponds to the poster). (1991).
Rees, D. D. et al. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br. J. Pharmacol. 96: 418-424, 1989.
Sakuma, I. et al. Identification of arginine as a precursor of endothlium-derived relaxing factor. Proc. Natl. Acad. Sci. USA. 85: 8664-8667, 1988.
Beckman, J. S. et al. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA. 87: 1620-1624, 1990.
Beckman, J. S. Ischaemic injury mediator. Nature 345: 27-28, 1990.
Nava, E. et al. The role of nitric oxide in endotoxin shock. Deleterious effects of N.sup.G -monomethyl-L-arginine and protective effects of dexmethasone. Poster presented at a meeting in the United Kingdom on The Biology of Nitrite Oxide (1991).
Proceeding Natl. Acad. Sci. USA; vol. 85; pp. 8664-8667; Nov. 1988; Sakuma et al.
Proc. Natl. Acd. Sci. USA: vol. 86: pp. 3375-3378 May 1989: D. D. Rees et al.
Dr. J. Pharmacal (1990), 101, pp. 746-752.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nitric oxide synthase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitric oxide synthase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitric oxide synthase inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1991631

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.