Nitric oxide synthase inhibitor phosphate salt

Details Nitric oxide synthase inhibitor phosphate salt Nitric oxide synthase inhibitor phosphate salt

2008-01-08

2008-01-08

Richter, Johann (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S631000, C560S148000, C562S556000, C564S225000

Reexamination Certificate

active

07317040

ABSTRACT:
A compound of formula (I):namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with phosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relatively non-hygroscopic selective inhibitor of inducible nitric oxide synthase.

REFERENCES:
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Bastin, et al. Salt selection and optimisation procedures for pharmaceutical new chemical entities. Organic Process & Development 2000, 4, 427-435.
Wikipedia Phosphoric acid Feb. 15, 2006.
Riedermann et al. Expert Opin. Biol. Ther. 2003, 3(2), 339-350.
Young et al.; “Inhibition of Inducible Nitric Oxide Synthase by Acetamidine Derivatives of Hetero-Substituted Lysine and Homolysine”; Bioorg. Med. Chem. Lett.; 2000; vol. 10(6); pp. 597-600.

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