Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of co-culturing cells
Reexamination Certificate
2005-03-08
2005-03-08
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of co-culturing cells
C435S404000
Reexamination Certificate
active
06864086
ABSTRACT:
Nitric oxide adversely affects survival and development of cells such as oocytes and embryos in vitro, particularly in a co-culture system. The addition of a nitric oxide inhibitor such as hemoglobin to such systems eliminates this toxic effect, and promotes mammalian oocytes, embryos, or other cells in vitro.
REFERENCES:
patent: WO 9527040 (1995-10-01), None
Dawson et al., PNAS USA 88:6368-6371 (Jul. 1991).
Dekel et al., Endocrinology 98(2): 498-504 (1976).
Eyestone, W. et al., “Co-culture of Early Cattle Embryos to the Blastocyst Stage with Oviductal Tissue or in Conditioned Medium,” J. Reprod. Fert. 85:715-720 (1989).
Fukuda, A. et al., Production of nitric oxide from mouse embryo and effect of nitrite on mouse embryonic development in vitro. Biol Reprod 54:173 (abstr) (1996) Reprod. Fertil. Dev. 8:1199-1205 (1996).
Gouge, R.C. et al., “Nitric Oxide as a Regulator of Embryonic Development,” Biology Of Reproduction, v. 58, pp. 875-879 (1998).
Haddad, E. et al., “Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells,”J. Exp. Med., 182, 1143-1151 (1995).
Jablonka-Shariff, A. et al., “Hormonal Regulation of Nitric Oxide Synthases and Their Cell-Specific Expression during Follicular Development in the Rat Ovary,” Endocrinology 138:460-468 (1997).
Juretic et al., Cellular Immunology 157: 462-477 (1994).
Katu{hacek over (s)}ić, Z. et al., “Nitric Oxide Synthase: From Molecular Biology to Cerebrovascular Physiology,” NIPS 9:64-67 (1994).
Lim, J. et al., “A Continuous Flow, Perifusion Culture System for 8- to 16-Cell Bovine Embryos Derived from In Vitro Culture,” Theriogenology 46:1441-1450 (1996).
Lim, J. et al., “A Serum-Free Medium for Use in a Cumulus Cell Co-Culture System for Bovine Embryos Derived from In Vitro Maturation and In Vitro Fertilization,” Theriogenology 45:1081-1089 (1996).
Lim, J. et al., “Intracytoplasmic glutathione concentration and the role of β-mercaptoethanol in preimplantation development of bovine embryos,”Theriogenology, 46, 429-439 (1996).
Lim, J. et al., “Perifusion Culture System for Bovine Embryos: Improvement of Embryo Development by Use of Bovine Oviduct Epithelial Cells, and Antioxidant and Polyvinyl Alcohol,” Reprod. Fertil. Dev., 9:411-418 (1997).
Lim, J. et al., “Roles of growth factors in the development of bovine embryos fertilized in vitro and cultured singly in a defined medium,”Reprod. Fertil. Dev., 8, 1199-1205 (1996).
McCann, S. et al., “The Role of Nitric Oxide in Reproduction,” Soc. for Experimental Biology and Medicine, pp. 7-15 (1996).
L. McDonald et al., “Nitric Oxide and Cyclic GMP Signaling,” Soc. for Experimental Biology and Medicine, pp. 1-6 (1996).
Novaro et al., “Nitric oxide synthase regulation during embryonic implantation,” Reprod. Fertil. Dev. 9:559-564 (1997).
Thibodeaux, J. et al., “Role of Platelet-Derived Growth Factor in Development of in vitro Matured and in vitro Fertilized Bovine Embryos,” J. Reprod. Fert. 98:61-66 (1993).
Thibodeaux, J. et al., “Stimulation of Development of In Vitro-Matured and In Vitro-Fertilized Bovine Embryos by Platelets,” J. Anim. Sci. 71: 1910-1916 (1993).
Vega, M. et al., “Expression of Nitric Oxide Synthase (NOS) in Human Corpus Luteum (hCL) and the Role of Nitric Oxide (NO) on Luteal Steroidogenesis” (abstract), Biol. Reprod., 54 (Suppl. 1):66 (1996).
Hansel William
Lim Jeong-Mook
Board of Supervisors of Louisiana State University and Agricultu
Runnels John H.
Witz Jean C.
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