Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones...

Details Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones... Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones...

2005-01-25

2009-11-24

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S165000, C514S533000, C560S011000, C558S275000

Reexamination Certificate

active

07622502

ABSTRACT:
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases.The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.

REFERENCES:
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patent: WO 95/30641 (1995-11-01), None
patent: WO 97/28120 (1997-08-01), None
patent: WO 98/09948 (1998-03-01), None
patent: WO 01/45703 (2001-06-01), None
patent: WO 03/084550 (2003-10-01), None
patent: WO 03/103602 (2003-12-01), None
patent: WO 2004/002420 (2004-01-01), None
patent: WO 2004/011421 (2004-02-01), None
patent: WO 2004/103955 (2004-12-01), None

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