Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2007-04-03
2007-04-03
Powers, Fiona T. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C558S482000
Reexamination Certificate
active
10521075
ABSTRACT:
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events
REFERENCES:
patent: 5733909 (1998-03-01), Black et al.
patent: 5849943 (1998-12-01), Atkinson et al.
patent: 6649629 (2003-11-01), Bandarage et al.
patent: 6706724 (2004-03-01), Khanapure et al.
patent: 2001/0041726 (2001-11-01), Bandarage et al.
patent: 2003/0220228 (2003-11-01), Bandarage et al.
patent: 2004/0053985 (2004-03-01), Bandarage et al.
patent: 2004/0072883 (2004-04-01), Garvey et al.
patent: 2004/0116431 (2004-06-01), Khanapure et al.
patent: 2004/0176331 (2004-09-01), Berthelette et al.
patent: 2005/0192346 (2005-09-01), Shi et al.
patent: 1 336 602 (2003-08-01), None
patent: WO 94/12463 (1994-06-01), None
patent: WO 95/30641 (1995-11-01), None
patent: WO 96/13483 (1997-04-01), None
patent: WO 97/16405 (1997-05-01), None
patent: WO 97/28120 (1997-08-01), None
patent: WO 01/45703 (2001-06-01), None
patent: WO 03/094924 (2003-11-01), None
patent: WO 03/103602 (2003-12-01), None
patent: WO 2004/000300 (2003-12-01), None
patent: WO 2004/000781 (2003-12-01), None
Blaine et al., J. Shoulder Elbow Surg, 14(1S), 84S-89S, 2005.
Kim et al., Clinical Therapeutics, 25(6), 1593-1617, 2003.
Nogawa et al., International Congress Series, 1215, 363-372, 2003.
Takasaki et al., Neuropharmacology, 49, 283-292, 2005.
Golub et al., Science, 286, 531-537, Oct. 15, 1999.
Berthelette Carl
Dufresne Claude
Lachance Nicholas
Li Lianhai
Sturino Claudio
Merck Frosst Company
Powers Fiona T.
Rose David L.
Yuro Raynard
LandOfFree
Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3754492