Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...
Reexamination Certificate
2011-06-28
2011-06-28
Cheung, William K (Department: 1762)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Polymers from only ethylenic monomers or processes of...
C424S426000, C424S078350, C424S423000, C564S512000, C546S122000, C546S014000, C546S297000, C546S307000, C546S082000
Reexamination Certificate
active
07968664
ABSTRACT:
The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2— group, wherein the N2O2— group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.
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Citro Michael L.
DeRosa Frank
Hrabie Joseph A.
Keefer Larry K.
Cheung William K
Leydig , Voit & Mayer, Ltd.
The United States of America as represented by the Department of
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