Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-03-11
1998-11-17
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514149, 514238, 514255, 514315, 514319, 514329, 514332, 514357, 514426, 514492, 514494, 514499, 514558, 514564, 514563, 514579, 514611, 514645, 514659, 514647, A61K 3113, A61K 3144, A61K 31495, A61K 31445
Patent
active
058377360
ABSTRACT:
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
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Krishna Murali C.
Liebmann James E.
Mitchell James B.
Russo Angelo
Wink, Jr. David A.
MacMillan Keith D.
The United States of America as represented by the Department of
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