Coating processes – Medical or dental purpose product; parts; subcombinations;...
Reexamination Certificate
2005-02-15
2005-02-15
Yoon, Tae H. (Department: 1714)
Coating processes
Medical or dental purpose product; parts; subcombinations;...
C427S002240, C427S002310, C623S926000, C424S426000, C977S726000
Reexamination Certificate
active
06855366
ABSTRACT:
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
REFERENCES:
patent: 4043331 (1977-08-01), Martin et al.
patent: 4524036 (1985-06-01), Gilding et al.
patent: 5024789 (1991-06-01), Berry
patent: 5376117 (1994-12-01), Pinchuk et al.
patent: 5519020 (1996-05-01), Smith et al.
patent: 5714511 (1998-02-01), Saavedra et al.
patent: 5770645 (1998-06-01), Stamler et al.
patent: 5814656 (1998-09-01), Saavedra et al.
patent: 6106913 (2000-08-01), Scardino et al.
patent: 6645518 (2003-11-01), Tedeschi et al.
patent: 0 030 786 (1981-06-01), None
patent: WO 96 32136 (1996-10-01), None
patent: WO 98 03267 (1998-01-01), None
Pulfer, Sharon K. et al.: “Incorporation of Nitric Oxide-Releasing Crosslinked Polyethyleneimine Microsperes into Vascular Grafts,”Journal of Biomedical Materials Research, vol. 37, no. 2, 1997, pp. 182-189.
Doshi, J. et al.: “Electrospinning Process and Applications of Electrospun Fibers,”Journal of Electrostatics, Aug. 1995, Netherlands, vol. 35, no. 2-3, pp. 151-160.
Smith, Daniel J. et al.: “Nitric Oxide-Releasing Polymers Containing the (N(O)NO)—Group,”Journal of Medicinal Chemistry, vol. 39, no. 5, 1996, pp. 1148-1156.
Bauer, Joseph A. et al.: “Evaluation of Linear Polyethyleneimine/Nitric Oxide Adduct on Wound Repair: Therapy versus Toxicity,”Wound Repair and Regeneration, vol. 6, no. 6, Nov., 1998, pp. 569-577.
Reneker Darrell H.
Smith Daniel J.
Roetzel & Andress LLP
The University of Akron
Yoon Tae H.
LandOfFree
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