Nitric oxide donors based on metallic centers

Details Nitric oxide donors based on metallic centers Nitric oxide donors based on metallic centers

2005-05-24

2005-05-24

McKenzie, Thomas C. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S253120, C514S255010, C544S360000, C544S382000

Reexamination Certificate

active

06897218

ABSTRACT:
A metal complex of a piperazineNONOate derivative of the formula:wherein a) R1and R2independently represent hydrogen, linear or branched (C1-C4) alkyl, optionally substituted by 1 or 2 groups selected from the group consisting of hydroxy, (C1-C4) alkoxy, (C1-C4) alkylthio, amino, (C1-C4) alkylamino, di-(C1-C4) alkylamino, carboxy, carbo(C1-C4) alkoxy, aryl, aryloxy, arylthio; orb) R1and R2taken together, represent one of the following groups ═CR3-aryl, where R3represents hydrogen, (C1-C4) linear or branched chain alkyl, optionally substituted by 1 or 2 groups selected from the group consisting of hydroxy, carboxy, aryl; n represents a whole number ranging from 2 to 4; M+represents a cation of a transition metal or zinc; x represents a whole number which varies from 1 to 3, and indicates the charge units of the cation of the transition metal or of the zinc in relation to its stable oxidation state; A − represents an inorganic or organic anion which forms stable salts with the NONOate metal complex; y represents a whole number which varies from 1 to 3, and indicates the charge of the anion; m represents a whole number including zero, or a fractional, indicating the number of anions required to balance the cationic charge of the NONOate metal complex and is related to the values of x, y, k and w by the relationship:m=(x+k)-(1+w)ywhere w is the number of possible further anionic charge units and k is the number of possible further cationic charge units present in the NONOate ligand substrate. The complex of the invention exhibits an endothelio-protective effect in the coronary system and stimulates re-endothelialization and angiogenesis proceses.

REFERENCES:
patent: 6133320 (2000-10-01), Yallampalli et al.
patent: 93 20088 (1993-10-01), None
patent: 96 40665 (1996-12-01), None
David J Webb; Ian L Megson , Expert Opinion on Investigational Drugs 2002, vol. 11, No. 5, pp. 587-601.*
J.A. Hrabie et al.: “New nitric oxide-releasing zwitterions derived from polyamines” Journal of Organic Chemistry, vol. 58, No. 6, pp. 1472-1476 1993.
J.A. Hrabie et al.: “Adducts of piperazine with nitric oxide” Organic Preparations and procedures Int., vol. 31, No. 2, pp. 189-192 1999.

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