Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1991-04-05
1994-02-08
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514513, 514625, 558482, 558483, A61K 3121, A61K 3116
Patent
active
052848728
ABSTRACT:
New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a thio ester thereof, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, coronary dilation, high blood pressure, cardiac insufficiency and for dilating the peripheral vessels.
REFERENCES:
patent: 4900719 (1990-02-01), Means
Lefer et al, Circulation (Sup II) 84:11-620, Abs. No. 2465 Oct. 1991.
Lefer et al. Circulation (Sup II) 84:11-673 Abst No. 2673 Oct. 1991.
Burger, "Medicinal Chemistry" p. 75, 1971.
Campbell Chem Abs. 78(21):136650e & RN38660-08-1, 1973.
JP02091054, Chem. Abs. 113(23):212672x Mar. 30, 1990.
Chemical Abstracts vol. 109, p. 43, (1988), entry 85991r Martin Feelisch et al.
Chemical Abstracts vol. 92, pp. 232 & 233, (1980) entry 176369r, Louis Ignarro et al.
Chemical Abstracts vol. 93, p. 260, (1980) entry 181779z, Louis Ignarro et al.
Chemical Abstracts, vol. 103, pp. 73 and 74 (1985) entry 206021m, H. Schroeder.
Chemical Abstracts, vol. 107, p. 43 (1987) entry 109095p, Martin Feelisch et al.
Campbell et al, J. Org. Chem., vol. 38, No. 6, (1973), pp. 1183-1186.
Feelisch Martin
Fritschi Edgar
Kanzler Ralf
Noack Eike
Sandrock Klaus
Hook Gregory
Schwarz Pharma AG
Waddell Frederick E.
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