Nitrato alkanoic acid derivatives, methods for their production,

Details Nitrato alkanoic acid derivatives, methods for their production, Nitrato alkanoic acid derivatives, methods for their production,

1991-04-05

1994-02-08

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514513, 514625, 558482, 558483, A61K 3121, A61K 3116

Patent

active

052848728

ABSTRACT:
New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a thio ester thereof, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, coronary dilation, high blood pressure, cardiac insufficiency and for dilating the peripheral vessels.

REFERENCES:
patent: 4900719 (1990-02-01), Means
Lefer et al, Circulation (Sup II) 84:11-620, Abs. No. 2465 Oct. 1991.
Lefer et al. Circulation (Sup II) 84:11-673 Abst No. 2673 Oct. 1991.
Burger, "Medicinal Chemistry" p. 75, 1971.
Campbell Chem Abs. 78(21):136650e & RN38660-08-1, 1973.
JP02091054, Chem. Abs. 113(23):212672x Mar. 30, 1990.
Chemical Abstracts vol. 109, p. 43, (1988), entry 85991r Martin Feelisch et al.
Chemical Abstracts vol. 92, pp. 232 & 233, (1980) entry 176369r, Louis Ignarro et al.
Chemical Abstracts vol. 93, p. 260, (1980) entry 181779z, Louis Ignarro et al.
Chemical Abstracts, vol. 103, pp. 73 and 74 (1985) entry 206021m, H. Schroeder.
Chemical Abstracts, vol. 107, p. 43 (1987) entry 109095p, Martin Feelisch et al.
Campbell et al, J. Org. Chem., vol. 38, No. 6, (1973), pp. 1183-1186.

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