NIP3 family of proteins

Details NIP3 family of proteins NIP3 family of proteins

2002-11-08

2008-11-18

Spector, Lorraine (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S012200, C435S069900, C435S325000, C435S320100

Reexamination Certificate

active

07452869

ABSTRACT:
Methods and compositions for modulating necrosis and for treating neurological and cardiovascular diseases are described. The inventors have shown that BNIP3 is involved in cell necrosis and cell death involved in cardiovascular and neurological diseases.

REFERENCES:
patent: 5847093 (1998-12-01), Bandman et al.
patent: 5858678 (1999-01-01), Chinnadurai
patent: 0733706 (1996-09-01), None
patent: WO98/29447 (1998-07-01), None
patent: WO 9927093 (1999-06-01), None
Freshney, Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc. 1983, New York, pp. 3 and 4.
Pitts et al. American Journal of Physiology-Heart 287:1801-1812, 2004.
Thomas et al. Nature Reviews: Genetics 4:346-358, 2003.
Thompson, FDA Consumer Magazine, pp. 1-6 (www.fda.gov/fdac/features/2000/500—gene.html) Sep.-Oct. 2000.
Thomas et al. Nature Biotechnology 18:39-42, 2000.
Chen et al. Journal of Experimental Medicine 186(12): 1975-1983, 1997.
Ray et al. Journal of Biological Chemistry 275(2): 1439-1448, Jan. 2000.
Vande Velde et al. Molecular and Cellular Biology 20(15): 5454-5468, Aug. 2000.
Guo et al. Cell Death and Proliferation 8: 367-376, 2001.
Regula et al. Journal of Molecular and Cellular Cardiology 38: 3-13, 2005.
Hamacher-Brady et al., Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy, Cell Death and Diff., 14:146-157, 2007.
Tygai et al., Internalization of HIV-1 Tat requires cell surface heparin sulfate proteoglycans, J. Biol. Chem. 276(5):3254-3261, 2001.
Bucci et al. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide syhtnesis and reduces inflammation, Nat. Med. 6(12):1362-1367, 2000.
Bernardi, P. L. et al. 1999. “Mitochondria and cell death: mechanistic aspects and methodological issues” Eur. J. Biochem. 264: 687-701.
Bialik, S. et al. “The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocyres” Circ. Res. Sep. 3, 1999 85: 403-414.
Bossy-Wetzel, E. et al., 1998. “Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independeritly of mitochondrial transmembrane depolarization” EMBRO J. 17: 37-49.
Boyd, J. M. et al. 1994. “Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins” Cell 79: 341-351.
Capecchi, M. R. “Altering the genome by homologous recombination” Science 244: 1288-1292 (1989).
Chautan, M. et al., 1999. “Interdigital cell death can occur through a necrotic and caspase-independent pathway” Curr. Biol. 9: 967-970.
Chen, G. et al., 1999 “Nix and Nip3 Form a Subfamily of Pro-apoptotic Mitochondrial Proteins”, J. Biol. Chem. 274: 7-10.
Chen, G. et al., 1997 “The E1B 19K Bcl-2 binding protein NIP3 is a dimeric mitochondrial protein that activates apoptosis”, J. Exp. Med. 186: 1975-1983.
Chi, S. et al., 1999. “Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells” Oncogene 18: 2281-2290.
Cizeau, J. et al. “The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism” Oncogene Nov. 16, 2000; 19 (Srinivasula, S. M. et al., 1998): 5453-63.
Cregg, J. M. et al. “Recent Advances in the Expression of Foreign Genes inPichia pastoris”, Bio/Technology 11: 905-910, 1993.
Crompton, M. 1999 “The mitochondrial permeability transition pore and its role in cell death” Biochem. J. 341: 233-249.
Datta, S. R. et al., 1997 “Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery”, Cell 91: 231-241.
Davies, N. P. et al., “Targeted alterations in yeast articial chromosomes for inter-species gene transfer”, Nucleic Acids Research, vol. 20, No. 11, pp. 2693-2698 (1992).
Déas, O. et al., 1998 “Caspase-Independent Cell Death Induced by Anti-CD2 or Staurosporine in Activated Human Peripheral T Lymphocytes”, J. Immunol. 161: 3375-3383.
de Moissac, D. et al., “Caspase Activation and Mitochondrial Cyrochrome C Release during Hypoxia-mediated Apoptosis of Adult Ventricular Myocytes” J. Mol. Cell Cardiol. 2000 32: 53-63.
Dickinson, P. et al. , “High frequency gene targeting using insertional vectors”, Human Molecular Genetics, vol. 2, No. 8, pp. 1299-1302 (1993).
Dixon, I. M., et al., “Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats”, Am J Physiol. 1992; 262: H1387-H1394.
Earnshaw, W. C. et al., 1999, “Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis” Annu. Rev. Biochem. 68: 383-424.
Finucane, D. M. et al., 1999, “Bax-induced Caspase Activation and Apoptosis via Cytochrome c Release from Mitochondria Is Inhibitable by Bcl-xL”, J. Biol. Chem. 274: 2225-2233.
Goping, I. S. et al., 1998 “Regulated Targeting of BAX to Mitochondria”, J. Cell. Biol. 143: 207-215.
Green, D. R. et al., 1998, “Mitochondria and Apoptosis”, Science 281: 1309-1312.
Griffiths, G. J. et al., 1999, “Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis”, J. Cell Biol. 144: 903-914.
Gross, A. et al., 1999, “BCL-2 family members and the mitochondria in apoptosis”, Genes Dev. 13: 1899-1911.
Gurevich, R. M. et al., “Serpin Protein CrmA Suppresses Hypoxia-Mediated Apoptosis of Ventricular Myocytes” Circulation 2001; 103: 1984-1991.
Huston, J. S. et al., 1991 “Protein Engineering of Single-Chain Fv Analogs and Fusion Proteins”, Methods in Enzymology, vol. 203: 46-88.
Hakem, R. et al., 1998, “Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo”, Cell 94: 339-352.
Harada, H. et al., 1999, “Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A”, Mol. Cell 3: 413-422.
Haughey, N. J. et al., (2001) “HIV-1 Tat through phosporylation of NMDA receptors potentiates glutamate excitotoxicity”, Journal of Neurochemistry 78, 457-467.
Horvitz, H. R. , 1999 “Genetic Control of Programmed Cell Death in the MenatodeCaenorhabditis elegans”, Cancer res. 59: 1701s-1706s.
Huxley, C. et al., “The Human HPRT Gene on a Yeast Artificial Chromosome Is Functional When Transferred to Mouse Cells by Cell Fusion”, Genomics, 9: 742-750 (1991).
Imazu, T. et al., 1999, “Bcl-2/E1b 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xLand induces apoptosis by altering mitochondrial membrane permeability”, Oncogene 18: 4523-4529.
Jakobovits, A. et al., “Germ-line transmission and expression of a human-derived yeast artificial chromosome”, Nature, vol. 362, pp. 255-261 (1993).
Johnson, S. et al., 1991, “Construction of Single-Chain Fv Derivatives of Monoclonal Antibodies and Their Production inEscherichia coli”, Methods in Enzymology, vol. 203: 88-99.
Kawahara, A. et al., 1998, “Caspase-independent Cell Killing by Fas-associated Protein with Death Domain”, J. Cell Biol. 143: 1353-1360.
Kerr, J. F. R., et al., 1972, “Apoptosis: A Basic Biological Phenomenon With Wide-Ranging Implications in Tissue Kinetics”, Br. J. Cancer 26: 239-257.
Kirshenbaum, L. A. et al., “The bcl-2 Gene Product Prevents Programmed Cell Death of Ventricular Myocytes”, Circulation. 1997 96: 1580-1585.
Kirshenbaum, L. A. et al., “Adenovirus E1A Represses Cardiac Gene Transcription and Reactivates DNA Synthesis in Ventricular Myocytes, via Alternative Pocket Protein- and p300-binding Domains”, J. Biol Chem. 1995; 270: 7791-7794.
Kirshenbaum, L. A., et al., “High Efficient Gene Transfer into Adult Ventricular Myocytes by Recombinant Adenovirus”, J. Clin. Invest. 1993 92: 381-387.
Kirshenbaum, L. A., et al., “Incr

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