Ninjurin

Details Ninjurin Ninjurin

1996-07-24

2000-10-31

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 235, 435 6, 435 691, 4353201, 4352523, C12N 1512, C12N 502

Patent

active

06140117&

ABSTRACT:
The present invention includes novel ninjurin proteins, peptides, and nucleic acids, as well as antibodies and pharmaceutical compositions comprising the same. The present invention further includes vectors and host cells comprising those nucleic acid sequences, chimeric protein and peptide molecules comprising the proteins and peptides of the present invention fused to heterologous polypeptide sequences. Also provided herein are antibodies which bind to the proteins and peptides of the present invention and methods for detecting the proteins and peptides of the present invention.

REFERENCES:
Dickson, G. et al., Cell, 50:1119-30, 1987.
Hasegawa et al., "Localization of E-Cadherin in Peripheral Glia After Nerve Injury and Repair," Medline (U.S. National Library of Medicine (NLM)), Accession No. 96228259 from Journal of Neuropathology and Experimental Neurology, 55(3):Abstract only (1996).
Lee et al., "Comparative Expressed-Sequence-Tag Analysis of Differential Gene Expression Profiles in PC-12 Cells Before and After Nerve Growth Factor Treatment," EMBL/Genbank Databases, Accession No H33513, Sequence Reference RS5132 (1995).
Okubo et al., "Gene Expression of Human Promyelocytic Cell Line HL60 Before and After Induction of Differentiation. A New Application of 3' Directed cDNA Sequencing," EMBL/Genbank Databases, Accession No. D20064, Sequence Reference HSGS01036 (1994).
Hillier et al., "The WashU-Merck EST Project," EMBL/Genbank Databases, Accession No. H91351, Sequence Reference HS351243 (1995).
Hillier et al., "The WashU-Merck EST Project," EMBL/Genbank Databases, Accession No. W38567, Sequence Reference HS567344 (1996).
Araki et al., "Ninjurin, A Novel Adhesion Molecule, Is Induced by Nerve Injury and Promotes Axonal Growth," Neuron, 17:353-361 (1996).
Lee et al., "Comparative Expressed-Sequence-Tag Analysis of Differential Gene Expression Profiles in PC-12 Cells Before and After Nerve Growth Factor Treatment," Proc. Natl. Acad. Sci. USA, 92:8303-8307 (1995).

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