NIMA interacting proteins

Details NIMA interacting proteins NIMA interacting proteins

1995-11-13

1999-10-26

Grimes, Eric

Chemistry: molecular biology and microbiology

Vector, per se

4352523, 536 231, 530350, C12N 1500

Patent

active

059726970

ABSTRACT:
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

REFERENCES:
patent: 5443962 (1995-08-01), Draetta et al.
Laura Chong, et al. "A Human Telomeric Protein," Science, vol. 270, Dec. 8, 1995, 1663-1667.
Lu et al., "Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans", EMBO Journal 1994, vol. 13, No. 9, pp. 2103-2113.
Osmani et al., "Mitotic Induction and Maintenance by Overexpression of a GS-Specific Gene That Encodes a Potential Protein Kinase", Cell. Apr. 22, 1988, vol. 53, pp. 237-244.
Lu et al., "Evidence for a Nima-Like Mitotic Pathway in Vertebrate Cells", Cell. May 5, 1995, vol. 81, pp. 413-424.
O'Connell et al., "Premature chromatin condensation upon accumulation of NIMA", EMBO Journal, 1994, vol. 13, No. 20, pp. 4926-4937.
Hillier et al. (1995) Accession No. H41102, EST-STS database.
Hillier et al. (1995) Accession No. T82035, EST-STS database.

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