Nifedipine-containing solid preparation composition

Details Nifedipine-containing solid preparation composition Nifedipine-containing solid preparation composition

1981-04-16

1983-11-01

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Lymphokine

424266, 424362, A61K 3179, A61K 31455, A61K 4700

Patent

active

044129866

ABSTRACT:
A novel nifedipine-containing solid pharmaceutical preparation composition comprising a mixture of nifedipine and at least one 1st(a) substance selected from polyvinyl pyrrolidone, methyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose; a mixture of nifedipine, at least one 1st(b) substance selected from polyvinyl pyrrolidone, urea, citric acid mannitol, succinic acid, methyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose and amino acid, and at least one 2nd substance selected from a surface active agent, polyethylene glycol, propylene glycol, glycerol, a glycerol fatty acid ester and a vegetable oil; or a mixture of nifedipine, the 1st(b) substance, the 2nd substance and calcium lactate.
The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered.

REFERENCES:
patent: 3784684 (1974-01-01), Bossert et al.
patent: 3799934 (1974-03-01), Meyer et al.
patent: 3862161 (1975-01-01), Bossert et al.
patent: 3920823 (1975-11-01), Meyer et al.
patent: 3932645 (1976-01-01), Meyer et al.
patent: 3943140 (1976-03-01), Bossert et al.
patent: 3959296 (1976-05-01), Bossert et al.
patent: 3971796 (1976-07-01), Bossert et al.

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