Nifedipine-containing pharmaceutical compositions and process fo

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

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424462, 424468, 424497, 514299, A61K 914, A61K 922, A61K 952

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active

051456834

ABSTRACT:
A pharmaceutical composition which comprises particles of a finely divided pharmaceutically acceptable water soluble diluent coated with microcrystalline particles of nifedipine, the majority of which have a particle size of 100 micrometers or less in the presence of polyvinyl-pyrrolidone, the polyvinylpyrrolidone being present in an amount of from 10 to 90% by weight based on the weight of the nifedipine. The incorporation of polyvinylpyrrolidone in an amount of less than the amount of nifedipine significantly slows the dissolution of nifedipine from the finished solid dosage form.

REFERENCES:
patent: 4412986 (1983-11-01), Kawata et al.
patent: 4562069 (1985-12-01), Hegasy et al.
patent: 4765990 (1988-08-01), Sugimoto et al.
patent: 4840799 (1989-06-01), Appelgren et al.
patent: 4880623 (1989-11-01), Piergiorgio et al.
Sugimoto et al., Drug Development in Industrial Pharmacy, 6(2) pp. 137-160 (1980).
Chem. Pharm. Bull., vol. 30, No. 12, I. Sugimoto et al, "Stability and bioavailability of Nifedipine in fine granules", 1982, pp. 4479-4488.
Chemical Abstracts, vol. 96, No. 14, I. Sugimoto et al, "Formulation study for increasing bioavailability of nifedipine" 1982, p. 382.

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