Nifedipine-containing form of administration and method for its

Details Nifedipine-containing form of administration and method for its Nifedipine-containing form of administration and method for its

1985-10-03

1990-01-16

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424 78, 424455, 514962, A61K 948, A61K 966

Patent

active

048942359

ABSTRACT:
An improved form of administration of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine-dicarboxylic acid-dimethylester (i.e., Nifedipine) is provided in which the Nifedipine is molecularly dispersed wihtin a solidified melt of polyethylene glycols which are liquid, semi-solid and solid at room temperature. The weight ratio of liquid to non-liquid polyethylene glycols in the solidified melt ranges from about 7:23 to 23:7, the solidification temperature of the mixture ranges from about 25.degree. C. to 62.degree. C. and the mixture has a viscosity of from about 1 to 180,000 poise when measured at 20.degree. C. in admixture with up to about 40 percent by weight of water.

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Kaken C.A. 95:225681J (1981) of Jpn. KT.K. 81, 115,726, Sep. 11, 1981, Nifedipine Formulations containing Polyethylene Glycol.

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