Nicotinic derivatives of glucosamine and related pharmaceutical

Details Nicotinic derivatives of glucosamine and related pharmaceutical Nicotinic derivatives of glucosamine and related pharmaceutical

1981-05-19

1982-11-09

Ford, John M.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 53, A61K 3170, C07H 506

Patent

active

043584411

ABSTRACT:
The nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate are described as having anti-lipolitic, hypocholesterolemizing and antiaterogenic activities, at an equal or higher level than those of nicotinic acid, without the objectionable side effects shown by the acid. To prepare the compounds of the invention, nicotinoyl chloride hydrochloride and glucosamine hydrochloride are reacted in an organic solvent at a temperature of between 40.degree. C. and 120.degree. C.

REFERENCES:
patent: 3934009 (1976-01-01), Gey et al.
patent: 3950324 (1976-04-01), Gey et al.
Jones et al., Chem. Abstracts, vol. 48, 1251h (1954).
Micheel et al., Chem. Abstracts, vol. 50, 11955h, (1956).

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