Nicotine analogs

Details Nicotine analogs Nicotine analogs

1984-04-06

1986-05-20

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40104

Patent

active

045902780

ABSTRACT:
This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.
The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.

REFERENCES:
patent: 4093620 (1978-06-01), Osdene et al.
patent: 4321387 (1982-03-01), Chavdarian et al.
Leete, J. Org. Chem., vol. 41, 1976, pp. 3438-3441.
Wasserman et al., Tet. Letters 21, pp. 1731-1734, 1975.

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