Nicotinates of alkanediols having hypolipidaemic activity and ph

Details Nicotinates of alkanediols having hypolipidaemic activity and ph Nicotinates of alkanediols having hypolipidaemic activity and ph

1982-04-19

1984-06-12

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546263, A61K 31455, C07D21380

Patent

active

044541457

ABSTRACT:
New compounds of general formula ##STR1## and salts therewith of pharmaceutically acceptable acids, wherein R and R.sub.1 independently represent a hydrogen atom or a straight or branched alkyl group having from 1 to 5 carbon atoms, and n is an integer from 4 to 12; and of general formula ##STR2## wherein R'.sub.1 represents a straight or branched alkyl group having from 2 to 4 carbon atoms, W represents hydroxymethyl or the COOM group in which M stands for a hydrogen atom, an alkali metal or an equivalent of an alkali earth metal and n is an integer from 6 to 8. The compounds are useful in treating hyperlipidaemia.

REFERENCES:
patent: 3637714 (1972-01-01), Carlson et al.
patent: 3742068 (1973-06-01), Moersch et al.
patent: 3857884 (1974-12-01), Moersch et al.
patent: 3930024 (1975-12-01), Creger
Drugs of the Future, vol. 11 (2), (1977) pp. 102-103.
Maxwell et al., Artery vol. 4 (4), (1978) pp. 303-313.
Abstracts of Papers from Clinical Pharmacology & Therapeutics, vol. 17 (2), pp. 229-230.
Abstract from Lipids, vol. 12, pp. 44-48 (1977).

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