Nicotinamide production

Details Nicotinamide production Nicotinamide production

1975-09-02

1977-02-15

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955R, C07D21356

Patent

active

040082415

ABSTRACT:
Nicotinamide is produced by aqueous ammonia hydrolysis of nicotinonitrile wherein the conversion is limited to at least 30% and no greater than 70%, with the nicotinonitrile concentration, expressed as weight product amide per 100 pounds of water, being at least 100 parts and no greater than 300 parts, with the hydrolysis being effected in the presence of ammonium nicotinate in an amount sufficient to essentially eliminate net production thereof. Ammonia and nicotinonitrile are stripped from the hydrolysis effluent, and nicotinamide recovered, by crystallization, from the stripped hydrolysis effluent.

REFERENCES:
krewson et al., Journal of the American Chemical Society, vol. 65 (11) pp. 2256-2257 (Nov. 1943).
Nikiforov et al., Chem. Abstracts, vol. 79 (21), 126, 259r, Nov. 26, 1973.

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