Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-01-13
1988-09-06
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514970, A61K 3144
Patent
active
047693819
ABSTRACT:
A non-liquid type preparation for injection that has improved stability contains N-(2-hydroxyethyl)-nicotinamide nitrate ester (generally known as nicorandil) and an inorganic or organic acid and/or an alkaline metal salt thereof. These ingredients, together with an excipient that is pharmaceutically acceptable, may be dissolved in a solvent, sterilized by filtration and freeze-dried to obtain a freeze-dried preparation, or may be dissolved in a solvent under an aseptic condition and recrystallized to obtain an injectable powder. Nicorandil preparations according to the present invention are very stable and useful in clinical applications.
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Iida Yoshimitsu
Ishihara Kouji
Matsuo Junko
Matsuo Naoki
Matsuoka Yoshinori
Chugai Seiyaku Kabushiki Kaisha
Robinson Douglas W.
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