Nicorandil containing external preparations

Details Nicorandil containing external preparations Nicorandil containing external preparations

1987-08-17

1989-05-23

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514355, 514946, 514947, A61L 1503

Patent

active

048329541

ABSTRACT:
The transdermal penetration of N-(2-hydroxyethyl) nicotinamide nitrate useful for the treatment of angina pectoris is improved by the use of a mixed solvent comprising an alcohol of 2 to 7 carbon atoms and an aliphatic ester having a molecular weight of at least 180 in the formulation of the external preparations.

REFERENCES:
patent: 4200640 (1980-04-01), Nagano et al.
patent: 4769381 (1988-09-01), Ishihara et al.
Kamiyama et al., CA. 106:201753d (1987), of Jpn. 6236317, Feb. 17, 1987.
Kuroodo et al., CA. 105:49085g (1986), of Jpn. 6178720, Apr. 22, 1986.

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