Ng-monomethyl-l-arginine hydrochloride derivatives and their use

Details Ng-monomethyl-l-arginine hydrochloride derivatives and their use Ng-monomethyl-l-arginine hydrochloride derivatives and their use

1998-04-07

1999-03-16

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562560, A01N 3710, C07C24100

Patent

active

058831304

ABSTRACT:
Crystalline N.sup.G -monomethyl-L-arginine hydrochloride is disclosed. At least three distinguishable isomorphic forms are present. The solid salt can be made by dissolving N.sup.G -monomethyl-L-arginine in hydrochloric acid and crystallising out N.sup.G -monomethyl-L-arginine hydrochloride. The crystallising step requires several months at low temperature. However, the process can be facilitated by seeding with crystals of N.sup.G -monomethyl-L-arginine hydrochloride. Alternatively, crystalline N.sup.G -monomethyl-L-arginine hydrochloride can be prepared by dissolving a salt of N.sup.G -monomethyl-L-arginine other than the hydrochloride salt with hydrochloric acid and removing the original salt forming ion by crystallising out the hydrochloride salt.

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Prabhakaran et al J.Am. Chem. Soc. 1988, 110, 5785-5791 Biosynthesis of Blasticidin S from L-.alpha.-Arginine etc.
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Scrip Display Apr. 27, 1998 Glaxo Wellcome hits problems in sepsis.

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