Ng-monomethyl-l-argine hydrochloride derivatives and their use i

Details Ng-monomethyl-l-argine hydrochloride derivatives and their use i Ng-monomethyl-l-argine hydrochloride derivatives and their use i

1995-06-02

1999-01-05

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

L07C24100

Patent

active

058565655

ABSTRACT:
A process for preparing crystalline N.sup.G -monomethyl-L-arginine hydrochloride is disclosed. The process comprises dissolving N.sup.G -monomethyl-L-arginine in hydrochloric acid and crystallising out N.sup.G -monomethyl-L-arginine hydrochloride. The crystallising step requires several months at low temperature. However, the process can be facilitated by seeding with crystals of N.sup.G -monomethyl-L-arginine hydrochloride. Alternatively, crystalline N.sup.G -monomethyl-L-arginine hydrochloride can be prepared by dissolving a salt of N.sup.G -monomethyl-L-arginine other than the hydrochloride salt with hydrochloric acid and removing the original salt forming ion by crystallising out the hydrochloride salt.

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