NF2 isoforms

Details NF2 isoforms NF2 isoforms

1994-01-10

1996-11-26

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4352523, 4353201, 530350, 536 221, 536 231, 536 235, C12P 2106, C12N 500, C07K 100, C07H 1900

Patent

active

055784623

ABSTRACT:
Novel human and mouse NF2 transcript isoforms and proteins encoded thereby, are disclosed. The isoforms are found in a variety of tissue and tumor types and represent differential processing of genomic DNA sequences, at the level of transcription, resulting in variant proteins. The isoforms provide useful tools for the analysis of the normal function of tumor suppressor factors, such as the merlin protein, and also provide useful markers for the detection of NF2 disease.

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