NFκB transcriptional activity inhibitory agent and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S300000

Reexamination Certificate

active

07932226

ABSTRACT:
It is intended to surely and effectively inhibit the transcriptional activity of NFκB and to obtain a more effective anti-inflammatory effect. Further, it is intended to obtain an equivalent effect even if the amount used of a steroid agent is reduced.An agent is characterized by containing MTI-II, especially a nucleic acid sequence of SEQ ID NO: 1, or a peptide of SEQ ID NO: 2. This MTI-II peptide is preferably a peptide containing at least an acidic amino acid domain (SEQ ID NO: 3). Further, a steroid agent such as triamcinolone acetonide is used concomitantly with MTI-II, especially the nucleic acid sequence of SEQ ID NO: 1 or the peptide of SEQ ID NO: 2.

REFERENCES:
patent: 6780970 (2004-08-01), Bonny
patent: 2004/0002521 (2004-01-01), Iino et al.
patent: 8-319238 (1996-12-01), None
patent: 9-59151 (1997-03-01), None
patent: 11-279057 (1999-10-01), None
patent: 2000-224993 (2000-08-01), None
patent: 2003-511071 (2003-03-01), None
patent: WO 02/26547 (2002-05-01), None
patent: WO 02/36547 (2002-05-01), None
patent: WO 03/016475 (2003-02-01), None
patent: WO 03/072035 (2003-09-01), None
Okamoto, et al., “The new type coactivator (MTI-ii) colocalizes with gulucocorticoid-receptor and enhances transcription through its acidic domain in vivo,”Seikagaku, vo. 76, No. 8, p. 1046, Aug. 25, 2004.
Okamoto, et al., “The nuclear acidic protein (MTI-II is a new type of nuclear-receptor coactivator,”Vitamins, vol. 78, No. 4, p. 283, 2004.
Scheinman, et al., “Characterization of Mechanisms Involved in Transrepression of KF-fB by activated Glucocoriticoid Receptors,”Molecular and Cellular Biology, Vo. 15, No. 2, p. 943-953, 1995.
International Search Report in PCT/JP2005/011851 dated Aug. 9, 2005.
Almawi et al., “Negative Regulation of Nuclear Factor-κB Activation and Function by Glucocorticoids,”J. Mol. Endo., 28(2):69-78 (2002).
D'Acquisto et al., “Inhibition of Nuclear Factor Kappa B (NF-κB): An Emerging Theme in Anti-Inflammatory Therapies,”Mol. Interv., 2(1):22-35 (2002).
Hannappel et al., “The Thymosins. Prothymosin α, Parathymosin, and β-Thymosins: Structure and Function,”Vitamins and Hormones, 66:257-296 (2003).
Leondiadis et al., “Synthesis, Mass Spectrometry Analysis and Potency of an Parathymosin (101 Amino Acids),”J. Peptide Sci., 8(Supp.):S118 (2002).
Okamoto et al., “Macromolecular Translocation Inhibitor II (Zn2+-Binding Protein, Parathymosin) Interacts with the Glucocorticoid Receptor and Enhances Transcription in Vivo,”J. Biol. Chem., 280(44):36986-36993 (2005).
Okamoto et al., “Purification and Primary Structure of a Macromolecular-Translocation Inhibitor II of Glucocorticoid-Receptor Binding to Nuclei from Rat Liver Inhibitor II is the 1 1.5-kDa Zn2+-Binding Protein (Parathymosin),”Eur. J. Biochem/FEBS, 267(1):155-162 (2000).
Salvin et al., “Potential Regulation of Immunity by the Peptides Prothymosin α and Parathymosin,”Lymphokine Res., 6(1):1437 (1987).
Salvin et al., “Regulation of Immune Responses by the Thymic Peptides, Prothymosin-α and Parathymosin-α1,”Natural Immunity and Cell Growth Regulation, 4(5):275 (1985).
Supplementary European Search Report for Application No. 05 75 5776, dated Aug. 24, 2009.
Okamoto, et al., “The nuclear acidic protein (MTI-II is a new type of nuclear-receptor coactivator,”Vitamins, vol. 78, No. 4, p. 263, 2004.

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