NF-κB activation inhibitors, and their pharmaceutical...

Details NF-κB activation inhibitors, and their pharmaceutical... NF-κB activation inhibitors, and their pharmaceutical...

2005-07-05

2005-07-05

Nickol, Gary (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S034000, C514S806000, C536S006400, C424S184100

Reexamination Certificate

active

06914046

ABSTRACT:
Compounds inhibiting the activation of the nuclear factor κB (NF-κB) are used for the preparation of medications adapted for the treatment of malignant hemopathies and solid tumors, and for the prevention of the appearance or the treatment, of phenomena of resistance to cytotoxic molecules used in the scope of treatment of the above pathologies, appearing in patients treated with these molecules when the latter are adapted to activate NF-κB.

REFERENCES:
patent: 5725851 (1998-03-01), Wong et al.
patent: 2002/0068690 (2002-06-01), Baldwin et al.
patent: WO 99/06040 (1999-02-01), None
Singh et al., Journal of Immunology, 1996, vol. 157, No. 10, pp. 4412-4420.
M.Digicaylioglu et al., Neuroprotection From Nitric Oxide by Erythropoietin (EPO) is Mediated by NFKappaB,Society for Neuroscience,Part 2, Los Angeles, CA, Nov. 7012, 1998.
A.Haeffner et al, Inhibitory Effect of Growth Hormone on TNF-alpha Secretion and Nuclear Factor -kappaB Translocation in Lipopolysaccharide-Stimulated Human Monocytes,Journal of Immunology, Feb. 1, 1997, vol. 3, No. 1, pp 1310-1314.
C.Y.Wang et al., TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-kappaB,Science, vol. 274, No. 5288, Nov. 1, 1996, pp 784-787.
A.Haeffner et al., Growth Hormone Prevents Human Monocyte Cell From FAS-Mediated Apoptosis by Up-Regulating Bcl-2 Expression,European Journal of Immunology, vol. 29, No. 1, Jan. 1999, pp 334-44.

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