Newly identified human epsilon immunoglobulin peptides and relat

Details Newly identified human epsilon immunoglobulin peptides and relat Newly identified human epsilon immunoglobulin peptides and relat

1990-04-27

1993-12-28

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

5303871, 5303879, C07K 710, C07K 1500

Patent

active

052740757

ABSTRACT:
The invention includes human .epsilon. chain transmembrane anchor peptide resulting from mRNA splicing other than the C.epsilon.4 exon, the .epsilon.m1 exon, and the .epsilon.m2 exon. Two new peptides in particular have been specifically identified. These novel peptides are not present in the conventional secreted (and circulating) IgE. These peptides provide antigenic sites for antibody binding. Thus, the invention further includes antibodies to such peptide segments, as well as such antibodies conjugated to cytotoxic agents, and their use in extracorporeal or in vivo therapy.

REFERENCES:
Ishida, N. et al., EMBO Journal, vol. 1(19): 1117-1123, 1982.
Ishida et al., The EMBO J. vol. 1 1117-23 (1982).
Word et al. "The Murine Immunoglobulin & Gene Expresses Multiple Transcripts from a unique membrane exon " (particularly; p. 895, 2nd column) EMBO Journal 2:887-898 (1983).

Affiliated with

Also associated with

Rating

Newly identified human epsilon immunoglobulin peptides and relat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Newly identified human epsilon immunoglobulin peptides and relat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Newly identified human epsilon immunoglobulin peptides and relat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1543682