Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-03-15
1991-05-07
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 530330, 530331, 560169, 562560, A61K 3702, C07C22924, C07C25102
Patent
active
050137239
ABSTRACT:
New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts.
The new compounds are enzyme-resistant immunomodulatory peptides.
REFERENCES:
patent: 4505853 (1985-03-01), Goldstein et al.
patent: 4547489 (1985-10-01), Goldstein et al.
patent: 4629723 (1986-12-01), Goldstein et al.
Archives of Biochemistry, vol. 242, No. 1, pp. 248-255, Oct. 1985, "Structural Requirements for the Biological Activity of Thymopentin Analogs".
Sisto Alessandro
Verdini Antonio
Eniricerche S.p.A.
Hollrah Glennon H.
Sclavo S.p.A.
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