New thiazolidine derivatives, process for preparing same and ant

Details New thiazolidine derivatives, process for preparing same and ant New thiazolidine derivatives, process for preparing same and ant

1991-12-19

1995-05-02

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548200, C07D41706, A61K 31425

Patent

active

054119766

ABSTRACT:
New thiazolidine derivatives of the general formula: ##STR1## wherein X stands for a proline or thioproline residue and R for --CH.sub.2 OH or --CHO, a process for preparing the same which comprises reacting N-benzyloxycarbonyl-L-proline or --L-thioproline with L-thioprolinol and, if necessary, oxidizing the resultant N-benzyloxycarbonyl-L-prolyl-L-thioprolinol or --L-thioprolyl-L-thioprolinol to the corresponding thioprolinal compound, and an anti-amnestic composition containing at least one of the thiazolidine derivatives together with a conventional excipient. The new thiazolidine derivatives are extremely strong in anti-amnestic activity when compared with known similar anti-amnestic agents.

REFERENCES:
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T. Yoshimoto et al., J. Pharmacobio-Dyn., vol. 10, pp. 730-735, (1987).
D. Tsuru et al., Journal of Biochemistry, vol. 104, No. 4, pp. 580-586, (1988).

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