New thiazole derivatives, and pharmaceutical composition compris

Details New thiazole derivatives, and pharmaceutical composition compris New thiazole derivatives, and pharmaceutical composition compris

1993-03-10

1994-11-15

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546275, 546276, 546250, 546284, A61K 3144, C07D41706

Patent

active

053648714

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 is amino, ureido, lower alkanoylamino, lower alkoxycarbonylamino, lower alkylsulfonylamino, lower alkoxy(lower)alkanoylamino, mono or di or trihalo(lower)alkanoylamino, hydroxy(lower)alkanoylamino, protected hydroxy(lower)alkanoylamino, or a group of the formula: ##STR2## in which R.sup.4 is hydrogen or sulfamoyl, R.sup.5 is amino or lower alkoxy, R.sup.2 is hydrogen, lower alkyl, lower alkoxy(lower)alkyl, di(lower)alkylamino(lower)alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, lower alkenyl or mono or di or trihalo(lower)alkyl; R.sup.3 is hydrogen or lower alkyl; or R.sup.2 and R.sup.3 are linked together to form lower alkylene,

REFERENCES:
patent: 4735957 (1988-04-01), Takaya et al.
Journal of Pharamacology and Experimental Therapeutics, vol. 24, pp. 129-135, 1990.
Drugs, vol. 32, pp. 15-47, 1986.
Yamanouchi Pharmaceuticals, "Chemical Abstract" 103(3), 1985, #22581n.
Yamanouchi Pharmaceutical, "Chemical Abstract" 103(9), 1985, #71307m.

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