New pyrimidines and a process for the preparation of pyrimidines

Details New pyrimidines and a process for the preparation of pyrimidines New pyrimidines and a process for the preparation of pyrimidines

1986-07-14

1987-12-29

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23930

Patent

active

047162295

ABSTRACT:
Pyrimidines substituted in the 5-position by fluorine, some of which are new, are prepared from pyrimidines of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and denote fluorine or trifluoromethyl,
by stepwise reaction with hydrogen chloride.

REFERENCES:
patent: 3314955 (1967-04-01), Boudakian et al.
patent: 3694444 (1972-09-01), Klauke et al.
Klauke et al., "Chemical Abstracts," vol. 98, 1982, col. 98:89312x.
Banks et al., "Chemical Abstracts," vol. 73, 1970, col. 25402c.
Protsenko, "Chemical Abstracts", vol. 65, 1966, col. 3869f.
Klauke et al., "J. Fluorine Chem.," vol. 21, 1982, pp. 495-513.
Morrison et al., Organic Chemistry, Sec. Ed., 1966, Allyn and Bacon, Inc., Boston, pp. 45-46.
Brown, Herocyclic Compounds, The Pyrimidines, Sup. I, 1970, Wiley-Interscience, New York, pp. 119-122.

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