Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1979-08-15
1981-05-12
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602395, 26023955R, C07J 7100, C07J 7300
Patent
active
042671060
ABSTRACT:
A process is disclosed for the preparation of 17.beta.-hydroxy-3-oxo-l7.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactone and 17.beta.-hydroxy-3-oxo-17.alpha.-pregna-4,6-diene-21-carboxylic acid .gamma.-lactone of the formula: ##STR1## wherein the dotted line between the 6-7 positions indicates an optional double bond, which is present in the latter compound, by reacting an androst-5-ene-17-one derivative with an organo-phosphorus compound. These lactones are valuable intermediates in the synthesis of spironolactone.
REFERENCES:
patent: 3382239 (1968-05-01), Barton
patent: 3632576 (1972-01-01), Lehmann et al.
patent: 3883512 (1975-05-01), Stache et al.
patent: 3900467 (1975-08-01), Irmscher et al.
Marx Arthur F.
Smid Peter M.
Vellekoop Pieter
Adams Bruce L.
Burns Robert E.
Gist Brocades N.V.
Lobato Emmanuel J.
Roberts Elbert L.
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