New process for manufacturing derivatives of 17 alpha-hydroxy 19

Details New process for manufacturing derivatives of 17 alpha-hydroxy 19 New process for manufacturing derivatives of 17 alpha-hydroxy 19

1985-08-19

1988-01-19

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, C07J 100

Patent

active

047203579

ABSTRACT:
A process for making a known 6-methyl, 19-nor-pregna-4, 6-diene, 3.20-dione which begins with formylating a 3-alcoxy, 19-nor-pregna-3,5,17(20)-triene at the 6 position. The 6-formylated derivative is reduced to yield a 6-hydroxy methylated derivative, which is in turn dehydrated to a 3-keto, 6-methylenic derivative. The 3-keto derivative is then isomerized to a 3-keto, 4,6,17-pregnatriene. This latter triene is then coverted to the known product by reaction with a bis-hydroxylating agent and a catalyst based on osmium tetroxide. Optionally, the product can be acylated at the 17-alpha position. The process reduces the cost of producing the known product by allowing it to be manufactured from starting materials less costly than those previously required.

REFERENCES:
patent: 3314944 (1967-04-01), Diassi et al.
patent: 3726864 (1973-04-01), Phillipps et al.
patent: 4224320 (1980-09-01), Dahl et al.

Affiliated with

Also associated with

Rating

New process for manufacturing derivatives of 17 alpha-hydroxy 19 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New process for manufacturing derivatives of 17 alpha-hydroxy 19, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New process for manufacturing derivatives of 17 alpha-hydroxy 19 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-370887