New preparation of placenta collagen, their extraction method an

Details New preparation of placenta collagen, their extraction method an New preparation of placenta collagen, their extraction method an

1991-01-07

1995-07-25

Schain, Howard E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

530356, C07K 1478

Patent

active

054361354

ABSTRACT:
Human or animal placenta is subjected to moderate enzymatic digestion, in particular with pepsin at an acid pH, then, after separation of the residual tissue the impurities are separated at a moderately acid pH, the collagen is precipitated at a neutral pH, redissolved and the residual impurities precipitated at an acid pH. The collagen obtained can be brought back to a neutral pH and dried in the form of fibres. Completely transparent, physiological and hemocompatible gels and solutions can be prepared. Applications for the fabrication of contact lenses and implants.

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Glanville et al., "Isolation and Characterization of a Native Placental Basement-Membrane Collagen and its Component & Chains" Eur. J. BioChem V95,383-389.
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Rauter et al, "Wound Healing Composition Containing Collagen from Basal Membranes" Chem Ab. V.98(24): 204394q, 1983.
Kresina et al, "Isolation and Characterization of Basement Membrane Collagen from Human Placental Tissue, Evidence for the Presence of Two Genetically Distinct Collagen Chains", Biochemistry V18(14) 3089-3097, 1979.
Isemura et al, "Thermoreversible Sol-gel transformation of Collagen Solution" Chem. Abstracts V.92(17) 142029g, 1979.
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