New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process

Details New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process

1977-08-30

1980-02-05

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265L, 260564G, 546145, 546176, 546193, 546194, 546211, 546 23, 548374, 544124, 544128, 544140, 544162, 548215, C07D29514, C07D40112, C07D40312

Patent

active

041872207

ABSTRACT:
A compound effective in the treatment of diabetic angiopathy, i.e. a selective .beta.-receptor blocker has the formula ##STR1## wherein: R.sup.2 is a hydrogen or alkyl having one to five carbon atoms, R.sup.3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R.sup.2 and R.sup.3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R.sup.5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R.sup.6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.

REFERENCES:
James et al., Nature New Biology, 243, (# 130) p. 276, (1973).

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