New N-acyl dipeptides and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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548496, C07C10352

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active

055433979

ABSTRACT:
Novel N-acyl depeptides of the formula:

REFERENCES:
Article entitled "Polymers Containing Enzymatically Degradable . . ." in Makromol, Chem. 182, 799-809 (1981).
Article entitled "Polymers Cont. Enzymatically Degrad. Bonds . . ." in Makromol Chem. 182, 1899-1915 (1981).
Article entitiled "Reactive Copolymers of N-(2-Hydroxypropl) . . ." Makromol. Chem. 178, 2169-2183 (1977).
Article entitled "Acyl-peptide Hydrolase from Rat Liver" in the Journal of Biol. Chem. 1987 vol. 262, No. 24, Aug. 25, pp. 11435-11445, 1987 by Kazumi Kobayashi and John A. Smith.
Article entitled "Inhibition by Bestatin of a Mouse Ascites Tumor Dipeptidase" in the Journal of Biol. Chem. 1989 vol. 264, No. 14, Issue of May 15, pp. 8004-8011, 1989 by Elizabeth K. Patterson Chemical Abstracts vol. 85, 1976 p. 578.
Chemical Abstracts vol. 111, 1989, p. 23.
Chemical Abstracts vol. 107, 1987 p. 350.
Cas Registry Handbook p. 99976-95-1 258RO;Number section 1984-Supplement 1433RM.
Blodgett et al, "Direct Cleavage versus Transpeptidation in the Autodecomposition of Peptides Containing 2,4-Diaminobutanoic Acid (DABA) and 2,3-Diaminopropanoic Acid (DAPA) Residues. Specific Cleavage of DAPA-Containing Peptides", Journal of the American Chemical Society, Aug. 1989, pp. 6813-6821.
Kobayashi et al, "Acyl-peptide Hydrolase from Rat Liver: Characterization of Enzyme Reaction", Journal of Biological Chemistry, Aug. 1987, pp. 11435-11445.
Bizzozero et al, "Serine-Protease-Assisted Synthesis of Peptide Substrates for a .alpha.-Chymotrypsin", Helvetica Chimica Acta, Sep. 1982, pp. 1707-1719.
Chemical Abstracts, vol. 110, No. 5, Jan. 30, 1989.
Patent Abtracts of Japan, Nov. 26, 1990, re: JP-A-02 286 624.

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