New lipopolyamines, their preparation and their use

Details New lipopolyamines, their preparation and their use New lipopolyamines, their preparation and their use

1994-02-03

1995-12-19

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C22900

Patent

active

054769620

ABSTRACT:
Intermediate compounds useful for producing transfecting lipopolyamines, comprising: ##STR1## wherein m is an integer between 2 and 6 inclusive, wherein n is an integer between 2 and 5 inclusive, wherein R.sub.5 represents a hydrogen atom or a carboxyl radical but no more than one R.sub.5 represents a carboxyl, the values of m in the different fragments (CH).sub.m may be identical or different, and wherein the symbol Z R.sub.5 represent a group protecting the amine function.

REFERENCES:
patent: 5171678 (1992-12-01), Behr et al.
Boeckman, Jr. et al, Journal of Organic Chemistry, vol. 51, #26, pp. 5486-5489, 1986.
Tetrahedron Letters, vol. 27, No. 48, 1986, pp. 5861-5864, Pergamon Journals Ltd., J. P. Behr, "DNA Strongly Binds to Micelles and Visicles Containing Lipopolyamines or Lipointercalants".
Proceedings of National Academy of Sciences of USA, vol. 86, No. 18 Sep. 1989, pp. 6982-6986 J. P. Behr, et al. "Efficient Gene Transfer into Mammalian Primary Endocrine Cells with Lipopolyamine-coated DNA".

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