New leukotriene-B.sub.4 derivatives, process for their productio

Details New leukotriene-B.sub.4 derivatives, process for their productio New leukotriene-B.sub.4 derivatives, process for their productio

1994-06-13

1995-05-09

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514530, 514573, 514729, 549273, 560121, 560231, 562503, 564189, 568838, C07C40500, A61K 31557

Patent

active

054140161

ABSTRACT:
Leukotriene-B.sub.4 derivatives of formula I ##STR1## are described, in which R.sup.1 means CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sup.5, CONR.sup.6 R.sup.7, or
R.sup.1 together with R.sup.2 means a carbonyl group,
R.sup.4 symbolizes H, C.sub.1 -C.sub.10 alkyl optionally substituted, C.sub.3 -C.sub.10 cycloalkyl, C.sub.6 -C.sub.10 aryl radical optionally substituted, or a 5-6-membered aromatic heterocyclic ring,
A symbolizes a trans, trans-CH.dbd.CH--CH.dbd.CH, a --CH.sub.2 CH.sub.2 --CH.dbd.CH-- or a tetramethylene group,
B symbolizes a C.sub.1 -C.sub.10 alkylene group, which optionally can be substituted by fluorine or the group ##STR2## D can mean a direct bond, oxygen, sulfur, --C.tbd.C--, --CH.dbd.CR.sup.6 or together with
B can also mean a direct bond, their salts with physiologically compatible bases and their cyclodextrin clathrates.

REFERENCES:
Vth International Conference on Prostaglandins, Florence (May 18-21, 1982), P. Borgeat et al.: "Inhibition of the synthesis of leukotriene B4 (LTB4) in human leukocytes by hydroxy-eicosatetraenoic acids", II.

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