New extractive process for the recovery of naturally occurring m

Details New extractive process for the recovery of naturally occurring m New extractive process for the recovery of naturally occurring m

1995-01-04

1996-04-16

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49816

Patent

active

055083986

ABSTRACT:
This invention relates to a process of recovering a neutral macrolide antibiotic, especially a tricyclic macrolide such as rapamycin from concentrates of fermentation broth extracts or mother liquors whereby acidic and/or basic components formed in the fermentation process are removed by utilizing aqueous base or acid extraction procedures from a water-immiscible solution of said concentrate and non-polar components are separated from the neutral macrolide by selective solubility.

REFERENCES:
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 5091389 (1992-02-01), Ondeyka
Sehgal, Baker and Vezina, J. of Antibiotics, 28(10)727 (1975).
Yohannes, Myers and Danishefsky, Tetrahedron Letters 34(13), 2075-2078 (1993).
Luengo, Konialian and Holt, Tetrahedron Letters 34(6), 991-994 (1993).
Steffan et al., Tetrahedron Letters 34(23), 3699-3702 (1993).
Yohannes and Danishefsky, Tetrahedron Letters 33(49), 7462-7472 (1992).

Affiliated with

Also associated with

Rating

New extractive process for the recovery of naturally occurring m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New extractive process for the recovery of naturally occurring m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New extractive process for the recovery of naturally occurring m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-326136