Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1987-12-16
1989-05-02
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
562450, 549 57, 549468, 548492, 546169, 514443, 514464, 514419, 514312, C07C10142
Patent
active
048268780
ABSTRACT:
New original derivatives are described of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxobutasnoic acids having the formula: ##STR1## in which n is 1 or 2, R.sub.1 is selected from the groups 2-naphthyl, 2 (or 3)-quinolinyl, 2 (or 3)-indolyl, 2 (or 3)-benzofuranyl, 2 (or 3)-benzothiophenyl, and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 or 5 carbon atoms, preferably pentyl, 2-ethoxyethyl, 3-methoxypropyl or 3-ethoxypropyl.
The compounds have a powerful antagonistic activity towards cholecystokinin and are particularly useful in the treatment of illnesses of the digestive system, such as colitis, biliary diskinesia, pancreatitis or in the treatment of disorders of the central nervous system imputable to deficiencies in the physiological neuron levels of cholecystokinin or other related bioactive polypeptides.
REFERENCES:
patent: 4439617 (1984-03-01), Sestanj et al.
Chemical Abstracts, vol. 103, No. 13, Abstract No. 99103r, Sep. 30, 1985.
Chiste Rolando
Makovec Francesco
Peris Walter
Rovati Luigi
Lee Mary C.
Northington Zinna
Rotta Research Laboratorium S.p.A.
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